Photo: iStockphoto.com/tunart
Cardiac Screening Prior to Stimulant Treatment of ADHD: A Survey of US-Based Pediatricians
Over the past decade, drug oversight committees and professional organizations have debated the evidence regarding cardiac screening to identify undiagnosed disorders associated with sudden cardiac death in youth with attention-deficit/hyperactivity disorder before beginning treatment with stimulants.
How practicing pediatricians have responded to this controversy is not known. We present results from a national sample of pediatricians regarding current attitudes, barriers, and practices for cardiac screening in youth with attention-deficit/hyperactivity disorder before prescribing stimulants. (Read the full article)
Caring for Cambodia
A Dutch couple quit their jobs and change the lives of youth on the other side of the world.
Cardinal Pell 'surprised' by Royal Commission findings
CNA Staff, May 7, 2020 / 11:00 am (CNA).- Cardinal George Pell has expressed his “surprise” at newly released findings of an Australian investigation, which concluded that the cardinal was aware of sexual abuse by clerics in the 1970s and 80s, and failed to act.
In 2017, Australia’s Royal Commission released a report on sexual abuse of minors in the country, the result of a five-year enquiry into the behavior and responsibility of institutions including the Church. Sections of the report relating to Cardinal Pell were redacted until the conclusion of criminal legal proceedings against the cardinal.
The redacted portions were released May 6.
In the newly available material, the commission found that Pell knew about the abusive activities of two priests during his own years as a priest, and that he failed to act to stop them.
On Thursday, Pell said through a spokesperson that the commission’s conclusions about him were “not supported by evidence.”
Pell gave evidence to the commission in 2016 via video link from Rome. During his testimony, he denied failing to act against known sexual abusers in the clergy. Pell specifically denied that while he was a priest in Ballarat in the 1970s and 80s, he had any awareness of the actions of then-Father Gerald Ridsdale, a serial abuser from the same diocese.
The Royal Commission concluded that, as a member of Bishop Ronald Mulkearns’ college of priest consulters in the diocese, Pell would have been made aware of allegations of abuse against Ridsdale during discussions about the priest’s transfers between assignments in 1977 and 1982.
But Pell told the commission that he and the other consulters had been deceived by Mulkearns and were unaware of Ridsdale’s crimes until years later.
“The Consultors who gave evidence on the meetings in 1977 and 1982 either said they did not learn of Ridsdale’s offending against children until much later or they had no recollection of what was discussed. None said they were made aware of Ridsdale’s offending at these meetings,” Pell said in a statement released through a spokesperson late Wednesday evening.
In a 2017 statement, Pell said “I would never have condoned or participated in a decision to transfer Ridsdale in the knowledge that he had abused children, and I did not do so.”
The commission rejected Pell’s testimony, and found that it “ought to have been obvious” why Ridsdale was being transferred from one assignment to another.
“We are satisfied Bishop Mulkearns gave reasons for it being necessary to move Ridsdale. We are satisfied that he referred to homosexuality at the meeting, in the context of giving reasons for Ridsdale’s move,” the report found. “However, we are not satisfied that Bishop Mulkearns left the explanation there, as Cardinal Pell said there would have been a discussion."
“We do not accept that Bishop Mulkearns lied to his consultors.”
The commission did not delineate specific proofs for its conclusion.
The commission also said that Pell would have known about allegations of abuse made against Fr. Peter Searson, who was active as a Melbourne priest during Pell’s time as an auxiliary bishop in the Melbourne archdiocese.
In 1989, Pell held a meeting with representatives from the parish and school in Doveton, where Searson was assigned. During that meeting a number of complaints were made against Searson but, according to Pell, sexual misconduct with children was not raised, and Searson’s removal was not requested.
Following Pell’s installation as Archbishop of Melbourne in 1996, Pell placed Searson on administrative leave and removed him from parish ministry in 1997. Searson died in 2009 and was never charged by police.
A spokesman for Victoria Police, which brought charges against Pell leading to his imprisonment for more than a year before the High Court freed him last month, told the Guardian that the newly released sections of the report would be studied and police would “undertake an assessment of those findings.”
“At this time it would not be appropriate to comment further about any possible action,” The spokesman said.
Current Archbishop of Melbourne Peter Comensoli released his own statement in response to the new material from the commission, in which he repeated his previous apologies “for the failure of the Catholic Archdiocese of Melbourne to responsibly care for and protect our young people and vulnerable adults.”
“Child safety and care is not a project with an end date”, Comensoli said, but a project that “requires life-long vigilance.”
In December 2018, Pell was convicted of five counts of sexual abuse, but was acquitted by the Australian High Court last monthl. Following that decision, the redacted portions of the commission’s findings were released.
Carey Price reaches out to brothers who lost their parents in N.S. mass shooting
Montreal Canadiens goaltender Carey Price has reached out to give support to two boys who lost their parents during the Nova Scotia mass shooting last month.
Cardinal tries to disavow petition that raises conspiracies about coronavirus lockdowns
Cardinal Robert Sarah, head of the Vatican's liturgy office, claims he never signed a petition claiming the coronavirus is an over-hyped "pretext" to deprive the faithful of Mass.
Cartoonists Comment on the Lasting Impact of Will Eisner (1917-2005)
The following is a guest post by Martha H. Kennedy, Curator of Popular & Applied Graphic Art, Prints & Photographs Division. During Will Eisner Week, March 1-7, 2020, the Library of Congress joins art schools, libraries, universities, and museums in a global celebration of this legendary creator’s contributions to the world of comic art and […]
Cardiologist worries heart patients denying themselves care over pandemic fears
A St. John's cardiologist says public health restrictions put in place under the COVID-19 pandemic, while justified, may be harming cardiac patients whose procedures have been postponed indefinitely as well as heart patients who are avoiding hospitals.
Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release
Dopaminergic neurons innervate extensive areas of the brain and release dopamine (DA) onto a wide range of target neurons. However, DA release is also precisely regulated. In Drosophila melanogaster brain explant preparations, DA is released specifically onto α3/α'3 compartments of mushroom body (MB) neurons that have been coincidentally activated by cholinergic and glutamatergic inputs. The mechanism for this precise release has been unclear. Here we found that coincidentally activated MB neurons generate carbon monoxide (CO), which functions as a retrograde signal evoking local DA release from presynaptic terminals. CO production depends on activity of heme oxygenase in postsynaptic MB neurons, and CO-evoked DA release requires Ca2+ efflux through ryanodine receptors in DA terminals. CO is only produced in MB areas receiving coincident activation, and removal of CO using scavengers blocks DA release. We propose that DA neurons use two distinct modes of transmission to produce global and local DA signaling.
SIGNIFICANCE STATEMENT Dopamine (DA) is needed for various higher brain functions, including memory formation. However, DA neurons form extensive synaptic connections, while memory formation requires highly specific and localized DA release. Here we identify a mechanism through which DA release from presynaptic terminals is controlled by postsynaptic activity. Postsynaptic neurons activated by cholinergic and glutamatergic inputs generate carbon monoxide, which acts as a retrograde messenger inducing presynaptic DA release. Released DA is required for memory-associated plasticity. Our work identifies a novel mechanism that restricts DA release to the specific postsynaptic sites that require DA during memory formation.
Effects of Attention on Orientation-Tuning Functions of Single Neurons in Macaque Cortical Area V4
Carrie J. McAdams
Jan 1, 1999; 19:431-441
Articles
CARL: Controllable Agent with Reinforcement Learning for Quadruped Locomotion. (arXiv:2005.03288v1 [cs.LG])
Motion synthesis in a dynamic environment has been a long-standing problem for character animation. Methods using motion capture data tend to scale poorly in complex environments because of their larger capturing and labeling requirement. Physics-based controllers are effective in this regard, albeit less controllable. In this paper, we present CARL, a quadruped agent that can be controlled with high-level directives and react naturally to dynamic environments. Starting with an agent that can imitate individual animation clips, we use Generative Adversarial Networks to adapt high-level controls, such as speed and heading, to action distributions that correspond to the original animations. Further fine-tuning through the deep reinforcement learning enables the agent to recover from unseen external perturbations while producing smooth transitions. It then becomes straightforward to create autonomous agents in dynamic environments by adding navigation modules over the entire process. We evaluate our approach by measuring the agent's ability to follow user control and provide a visual analysis of the generated motion to show its effectiveness.
Carly Tarkari Dodd : shackled excellence : 1 October - 10 December 2019 / curated by Adele Sliuzas ; photography by Morgon Sette.
Carly Dodd is a KaurnaNarungga and Ngarrindjeri artist. Carly mixes traditional and contemporary techniques, to produce works that are conceptually and culturally driven. Jack Buckskin is a Kaurna, Narungga and Wirangu man, born in the Adelaide Plains region, who has dedicated himself to learning and sharing the Kaurna language and culture.
Carlos / L.J. Diva..
Follow the meteoric rise of 70s porn star, Carlo Stefan, and the rocky path he took to find the life and love he craved in the Porn Star Brothers series. Carlos Stephanopoulos is the eldest of three brothers. Australian born and Greek Island raised, he loves women, sex, and money, and not necessarily in that order. He lives the good life, screwing women of all ages morning, noon and night until one night the good life comes to a screeching halt. On the run with only a suitcase and money, he winds up in Hollywood working in porn movies, with a new name and new look, only to become the biggest porn star around... but his troubles are not over.
Cardiac Manifestations of Congenital Generalized Lipodystrophy
Vani P. Sanon
Oct 1, 2016; 34:181-186
Feature Articles
Caramel slice
Base 1 cup (150g) plain flour 1 cup (150g) plain flour 1/2 cup (40g) desiccated coconut 1/2 cup (90g) brown sugar 125g unsalted butter, melted Filling 1/3 cup (115g) golden syrup 125g unsalted butter 2 x 395g sweetened condensed milk Pinch salt Topping 200g dark chocolate 1 tbs vegetable oil
Carrot Top Pesto
This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Cassie Duncan from Sustainable Table.
Careful what you wish for…
So around two months ago, as the novel coronavirus was just breaking in the Western media, I wrote a post bemoaning the culture of carbon-intensive academic travel. Funny — here we are, barely a quarter of the way into the … Continue reading
Care to Know the Motivation Behind That Gift, Love?
If you happen to stop by a Victoria's Secret store this Wednesday evening, on the eve of Valentine's Day, you will learn something fascinating about human nature that will tell you a lot about people and relationships.
Cardiovascular Risk Reduction With Liraglutide: An Exploratory Mediation Analysis of the LEADER Trial
The LEADER trial (ClinicalTrials.gov reg. no. We performed exploratory analyses to identify potential mediators of the effect of liraglutide on major adverse CV events (MACE; composite of CV death, nonfatal myocardial infarction, or nonfatal stroke) from the following candidates: glycated hemoglobin (HbA1c), body weight, urinary albumin-to-creatinine ratio (UACR), confirmed hypoglycemia, sulfonylurea use, insulin use, systolic blood pressure, and LDL cholesterol. These candidates were selected as CV risk factors on which liraglutide had an effect in LEADER such that a reduction in CV risk might result. We used two methods based on a Cox proportional hazards model and the new Vansteelandt method designed to use all available information from the mediator and to control for confounding factors. Analyses using the Cox methods and Vansteelandt method indicated potential mediation by HbA1c (up to 41% and 83% mediation, respectively) and UACR (up to 29% and 33% mediation, respectively) on the effect of liraglutide on MACE. Mediation effects were small for other candidates. These analyses identify HbA1c and, to a lesser extent, UACR as potential mediators of the CV effects of liraglutide. Whether either is a marker of an unmeasured factor or a true mediator remains a key question that invites further investigation.
CARES Act becomes law
The House passed a $2 trillion stimulus package March 27 aimed at helping the people, states and businesses nationwide devastated by the coronavirus pandemic that was later signed into law by President Donald Trump.
Caribbean Immigrants in the United States
Caribbean immigrants represent 10 percent of the 44.5 million immigrants in the United States, with the vast majority coming from just five countries: Cuba, the Dominican Republic, Jamaica, Haiti, and Trinidad and Tobago. Depending on their origin country and period of arrival, immigrants from the Caribbean have varying skill levels, racial composition, language background, and motivations for migration, as this article explores.
Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors Expert Forum
William T. Cefalu
Jan 1, 2018; 41:14-31
Diabetes Care Expert Forum
Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors Expert Forum
William T. Cefalu
Jan 1, 2018; 41:14-31
Diabetes Care Expert Forum
Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association
Caroline S. Fox
Sep 1, 2015; 38:1777-1803
Scientific Statement
Cartels and Competition in Minerals Markets: Challenges for Global Governance
19 December 2014
This research paper sets out recommendations for enhanced dialogue and intensified international cooperation that could significantly improve the functioning of global mineral markets.
The purpose of this research paper is to identify and analyse the key policy challenges associated with anti-competitive practices in international metals and minerals markets.
Recommendations
Enhanced dialogue and intensified international cooperation in four areas could significantly improve the functioning of global mineral markets:
- Deal with the last remnants of producer-country cartels
Consumer countries should make a publicly visible case that in an age of interdependence and global supply chains, any remaining forms of producer-country cartels are an anachronism. Given limited means to coerce governments to stop supporting the last remaining mineral cartels in potash, a ‘naming and shaming’ approach in key forums such as the Group of Twenty (G20) and the Organization for Economic Cooperation and Development (OECD) is likely to be most effective. Such action could be initiated by the three largest potash importers China, India and Brazil, and should seek support from others such as the EU and Japan.
- Prevent damaging export restrictions through win-win arrangements
WTO litigation against export restrictions is unlikely to be a silver bullet and in the short term cooperative policy dialogues, such as those pursued by the OECD, offer the best prospects for concrete results. Such dialogues should also be initiated by major emerging economies and could focus on providing incentives such as investment packages or technology-sharing to entice producer countries to abstain from imposing restrictions. Consumers should continue to push for more specific and stricter WTO rules on export restrictions. Japan, the EU and the US should seek to include similar measures in regional trade negotiations.
- Strengthen cooperation among regulators on clandestine private cartels and other anti-competitive practices
Concerted action will be required by governments to tackle anti-competitive practices such as clandestine cartels, price-fixing and territorial agreements. Key regulators, such as those in the EU and China, should expand collection and sharing of data and best practice on anti-trust enforcement in minerals markets. In key cases they could also coordinate prosecution. Sustained investment in institutional capacity is required in many emerging economies; this should be supported through bilateral cooperation and via regional forums. Governments should also resuscitate the stalled negotiations on the WTO’s role in competition policy.
- Enhance governance for transnational market platforms and pricing mechanisms
The responsibility to regulate key nodes in global minerals markets will remain in the hands of national bodies, but coordination is vital given interconnected global markets. International organizations and regulators should strengthen structural cooperation and exchange in the area of physical markets and with greater involvement of emerging economies. An informal high-level forum on regulating physical markets could reinvigorate debate, foster new perspectives and stimulate new partnerships. Governments in key consumer countries should also give their national regulators a clear mandate in minerals markets.
Department/project
CARPHA urges public to guard against mosquito-borne diseases
PORT OF SPAIN, Trinidad, CMC – The Trinidad-based Caribbean Public Health Agency (CARPHA) is urging people in the region to remember that despite the coronavirus (COVID-19) pandemic, they must be mindful that other public health threats still...
Care cash rush
Scores of people who turned up yesterday at the Pavilion Mall to collect their government-issued compassionate grants at Western Union made a mockery of physical distancing as they converge on the financial institution. There were long lines...
Carers need a voice in the NHS
Until recently, The BMJ had a campaign of patient partnership - now we have a patient and public partnership campaign. The reason for that change is that medicine has an effect beyond the individual being treated - and this podcast interview is a very good example of that. Anya De Iong, patient editor for The BMJ, talks to Christine Morgan -...
How does lifestyle affect genetic risk of stroke?
Cardiovascular factors are associated with risk of stroke - and those factors can be mediated by lifestyle and by genetic make up. New research published by The BMJ sets out to explore how these risks combine, and we're joined on the podcast by two of the authors - Loes Rutten-Jacobs, senior postdoctoral researcher at the German Center for...
Caring for renal transplant patients
Renal transplantation improves quantity and quality of life compared with chronic dialysis. A UK general practice with 8000 patients will have around four patients with a functioning renal transplant, one patient on the transplant waiting list, and several under consideration for transplantation. Many medical problems in renal transplant...
Caring for patients with delirium at the end of their life
Delirium is common in the last weeks or days of life. It can be distressing for patients and those around them. A clinical update explains why successful management involves excluding reversible causes of delirium and balancing drugs that may provoke or maintain delirium while appreciating that most patients want to retain clear cognition at the...
Carbon Capture and Storage: Panacea or Procrastination?
Research Event
14 September 2009 - 12:00am to 11:00pm
Chatham House, London
Event participants
Dr Jon Gibbins, Senior Lecturer in the Department of Mechanical Engineering, Imperial College London
Jim Footner, Senior Climate Change Campaigner, Greenpeace
Carbon capture and storage (CCS) has risen up the political agenda both nationally and internationally as a part of the effort to reduce CO2 emissions in power generation yet the applications, potential and impacts of this technology remain contested.
Is CCS - employed to produce low-carbon electricity and hydrogen - the panacea we urgently need to limit cumulative CO2 emissions to a level at which we stand a chance of avoiding dangerous climate change (and possibly also a renaissance in global nuclear fission)? Or does it shift the emphasis away from switching to more a sustainable renewable energy infrastructure that could avoid the use of fossil fuels and nuclear altogether?
In this meeting two leading voices in the debate give their opinions, separating the known from the unknown and kick starting an informed discussion about the pros, cons and politics of CCS.
Please note that attendance is by invitation only and there is a maximum of 25 places.
This meeting is part of the Chatham House Fossil Fuels Expert Roundtable.
Event attributes
All-day eventCareful as you go
A time will come, When you don’t even, Own your own body, On the side of the road, A full breakdown not a common, Puncture, Leave your heart, it’s broken, Total mechanical failure. What will you do? Trust what you have given? Love, a blue opinion? You have only what you spent. You think you […]
Card trick
Dance music, Damp heat and talk Drifts to halcyon days of, Seventies groove and Afro’s ruffled, In the political funk of, Freedom fighters and platform shoes, Cadillac language, Smooth and languid, Dripping off honey colored lips like, Melting chocolate… It’s a card trick, And we are mesmorised by, Furtive glances, Over fanned cards, Fascinated by […]
Cardiac Magnetic Resonance Myocardial Feature Tracking for Optimized Risk Assessment after Acute Myocardial Infarction in Patients with Type 2 Diabetes
Type 2 diabetes mellitus predicts outcome following acute myocardial infarction (AMI). Since underlying mechanics are incompletely understood, we investigated left ventricular (LV) and atrial (LA) pathophysiological changes and their prognostic implications using cardiovascular magnetic resonance (CMR). Consecutive patients (n=1147, n=265 diabetic; n=882 non-diabetic) underwent CMR 3 days after AMI. Analyses included LV ejection fraction (LVEF), global longitudinal, circumferential and radial strains (GLS, GCS and GRS), LA reservoir, conduit and booster pump strains, as well as infarct size, edema and microvascular obstruction. Predefined endpoints were major adverse cardiovascular events (MACE) within 12 months. Diabetic patients had impaired LA reservoir (19.8 vs. 21.2%, p<0.01) and conduit strains (7.6 vs. 9.0%, p<0.01) but not ventricular function or myocardial damage. They were at higher risk of MACE than non-diabetic patients (10.2% vs. 5.8%, p<0.01) with most MACE occurring in patients with LVEF≥35%. Whilst LVEF (p=0.045) and atrial reservoir strain (p=0.024) were independent predictors of MACE in non-diabetic patients, GLS was in diabetic patients (p=0.010). Considering patients with diabetes and LVEF≥35% (n=237), GLS and LA reservoir strain below median were significantly associated with MACE. In conclusion, in patients with diabetes, LA and LV longitudinal strain permit optimized risk assessment early after reperfused AMI with incremental prognostic value over and above LVEF.
Group Education in Diabetes: Effectiveness and Implementation
Carolé R. Mensing
Apr 1, 2003; 16:
Articles
Association of Self-Efficacy and Self-Care With Glycemic Control in Diabetes
Carla Moore Beckerle
Aug 1, 2013; 26:172-178
Feature Articles
Nutritional Management of Gastroparesis in People With Diabetes
Carol Rees Parrish
Oct 1, 2007; 20:231-234
Nutrition FYI
Pharmacotherapy for Hyperglycemia in Noncritically Ill Hospitalized Patients
Carlos E. Mendez
Aug 1, 2014; 27:180-188
From Research to Practice
Carbohydrate Content in the GDM Diet: Two Views: View 1: Nutrition Therapy in Gestational Diabetes: The Case for Complex Carbohydrates
Teri L. Hernandez
May 1, 2016; 29:82-88
From Research to Practice
Carbon footprint hotspots: Mapping China's export-driven emissions
(University of Michigan) The coronavirus pandemic has highlighted just how reliant the United States and other countries are on Chinese manufacturing, with widespread shortages of protective medical gear produced there.
Preparing to Prescribe Plant-Based Diets for Diabetes Prevention and Treatment
Caroline Trapp
Feb 1, 2012; 25:38-44
Nutrition FYI
Role of Physical Activity for Weight Loss and Weight Maintenance
Carla E. Cox
Aug 1, 2017; 30:157-160
From Research to Practice